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1

The Cancer Genome Atlas Pan-Cancer analysis project

Chang, Kyle, Creighton, Chad J, Davis, Caleb, Donehower, Lawrence, Drummond, Jennifer, Wheeler, David, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron S N, Chu, Andy, Chuah, Eric,

Journal:

Nature Genetics

Year:

2013

Language:

english

File:

PDF, 608 KB

english, 2013

2

55K isoform of CDK9 associates with Ku70 and is involved in DNA repair

Hongbing Liu, Christine H. Herrmann, Karen Chiang, Tzu-Ling Sung, Sung-Hwan Moon, Lawrence A. Donehower, Andrew P. Rice

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 722 KB

english, 2010

3

[ACM Press the 20th ACM SIGKDD international conference - New York, New York, USA (2014.08.24-2014.08.27)] Proceedings of the 20th ACM SIGKDD international conference on Knowledge discovery and data mining - KDD '14 - Automated hypothesis generation based on mining scientific literature

Spangler, Scott, Myers, Jeffrey N., Stanoi, Ioana, Kato, Linda, Lelescu, Ana, Labrie, Jacques J., Parikh, Neha, Lisewski, Andreas Martin, Donehower, Lawrence, Chen, Ying, Lichtarge, Olivier, Wilkins,

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

4

Exercise Effects on Tumorigenesis in a p53-Deficient Mouse Model of Breast Cancer

COLBERT, LISA H., WESTERLIND, KIM C., PERKINS, SUSAN N., HAINES, DIANA C., BERRIGAN, DAVID, DONEHOWER, LAWRENCE A., FUCHS-YOUNG, ROBIN, HURSTING, STEPHEN D.

Journal:

Medicine & Science in Sports & Exercise

Year:

2009

Language:

english

File:

PDF, 317 KB

english, 2009

5

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Totoki, Yasushi, Tatsuno, Kenji, Covington, Kyle R, Ueda, Hiroki, Creighton, Chad J, Kato, Mamoru, Tsuji, Shingo, Donehower, Lawrence A, Slagle, Betty L, Nakamura, Hiromi, Yamamoto, Shogo, Shinbrot, E

Journal:

Nature Genetics

Year:

2014

Language:

english

File:

PDF, 1.08 MB

english, 2014

6

Effect of Intragastric Application of N-Methylnitrosourea in p53 Knockout Mice

Hiroko Ohgaki, Masakatsu Fukuda, Yasuo Tohma, Huatao Huang, George Stoica, Masae Tatematsu, Lawrence A. Donehower

Journal:

Molecular Carcinogenesis

Year:

2000

Language:

english

File:

PDF, 269 KB

english, 2000

7

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Jones, Stephen N., Roe, Amy E., Donehower, Lawrence A., Bradley, Allan

Journal:

Year:

1995

File:

PDF, 838 KB

1995

8

MLH1 -silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes

Donehower, Lawrence A, Creighton, Chad J, Schultz, Nikolaus, Shinbrot, Eve, Chang, Kyle, Gunaratne, Preethi H, Muzny, Donna, Sander, Chris, Hamilton, Stanley R, Gibbs, Richard A, Wheeler, David

Journal:

The Journal of Pathology

Year:

2013

Language:

english

File:

PDF, 573 KB

english, 2013

9

Complementation of human immunodeficiency virus type 1 vif mutants in some CD4+ T-cell lines

Hevey, Michael, Donehower, Lawrence A.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.12 MB

english, 1994

10

Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53 +/- Mouse Model in Carcinogenicity Testing

Venkatachalam, Sundaresan, Tyner, Stuart, Pickering, Curtis, Boley, Scott, Recio, Leslie, French, John, Donehower, Lawrence

Journal:

Toxicologic Pathology

Year:

2001

Language:

english

File:

PDF, 424 KB

english, 2001

11

Medulloblastomas overexpress the p53-inactivating oncogeneWIP1/PPM1D

Robert C. Castellino, Massimiliano De Bortoli, Xiongbin Lu, Sung-Hwan Moon, Thuy-Ai Nguyen, Mark A. Shepard, Pulivarthi H. Rao, Lawrence A. Donehower, John Y. H. Kim

Journal:

Journal of Neuro-Oncology

Year:

2008

Language:

english

File:

PDF, 534 KB

english, 2008

12

The Tumorigenic Potential and Cell Growth Characteristics of p53-Deficient Cells are Equivalent in the Presence or Absence of Mdm2

Stephen N. Jones, Arthur T. Sands, Amy R. Hancock, Hannes Vogel, Lawrence A. Donehower, Steven P. Linke, Geoffrey M. Wahl and Allan Bradley

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.36 MB

english, 1996

13

Notch Activation as a Driver of Osteogenic Sarcoma

Tao, Jianning, Jiang, Ming-Ming, Jiang, Lichun, Salvo, Jason S., Zeng, Huan-Chang, Dawson, Brian, Bertin, Terry K., Rao, Pulivarthi H., Chen, Rui, Donehower, Lawrence A., Gannon, Francis, Lee, Brendan

Journal:

Year:

2014

Language:

english

File:

PDF, 3.70 MB

english, 2014

14

Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes

Wang, Linghua, Ni, Xiao, Covington, Kyle R, Yang, Betty Y, Shiu, Jessica, Zhang, Xiang, Xi, Liu, Meng, Qingchang, Langridge, Timothy, Drummond, Jennifer, Donehower, Lawrence A, Doddapaneni, Harshavard

Journal:

Nature Genetics

Year:

2015

Language:

english

File:

PDF, 2.38 MB

english, 2015

15

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

Lee, Susie, Donehower, Lawrence A., Herron, Alan J., Moore, David D., Fu, Loning, Beier, Frank

Journal:

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

16

Mouse models in tumor suppression

Ghebranious, Nader, Donehower, Lawrence A

Journal:

Year:

1999

Language:

english

File:

PDF, 430 KB

english, 1999

17

Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53

Cui, Xian-Shu, Donehower, Lawrence A

Journal:

Year:

2000

Language:

english

File:

PDF, 415 KB

english, 2000

18

Retroviral Vector-Mediated Transduction of K- ras Antisense RNA into Human Lung Cancer Cells Inhibits Expression of the Malignant Phenotype

Zhang, Yujiao, Mukhopadhyay, Tapas, Donehower, Lawrence A., Georges, Renee N., Roth, Jack A.

Journal:

Human Gene Therapy

Year:

1993

Language:

english

File:

PDF, 8.99 MB

english, 1993

19

Phase I Study of Non-Replicating Autologous Tumor Cell Injections Using Cells Prepared With or Without GM-CSF Gene Transduction in Patients with Metastatic Renal Cell Carcinoma. Johns Hopkins Oncology Center, Baltimore, Maryland

Berns, Anton J. M., Clift, Shirley, Cohen, Lawrence K., Donehower, Ross C., Dranoff, Glenn, Hauda, Karen M., Jaffee, Elizabeth M., Lazenby, Audrey J., Levitsky, Hyam I., Marshall, Fray F., Mulligan, R

Journal:

Human Gene Therapy

Year:

1995

Language:

english

File:

PDF, 1.89 MB

english, 1995

20

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Donehower, Lawrence A., Soussi, Thierry, Korkut, Anil, Liu, Yuexin, Schultz, Andre, Cardenas, Maria, Li, Xubin, Babur, Ozgun, Hsu, Teng-Kuei, Lichtarge, Olivier, Weinstein, John N., Akbani, Rehan, Whe

Journal:

Year:

2019

Language:

english

File:

PDF, 5.15 MB

english, 2019

21

Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging

George W. Hinkal, Catherine E. Gatza, Neha Parikh, Lawrence A. Donehower

Journal:

Mechanisms of Ageing and Development

Year:

2009

Language:

english

File:

PDF, 1.28 MB

english, 2009

22

The Nature of the Heterozygous Trp 53 Knockout Model for Identification of Mutagenic Carcinogens

French, John, Storer, Richard, Donehower, Lawrence

Journal:

Toxicologic Pathology

Year:

2001

Language:

english

File:

PDF, 256 KB

english, 2001

23

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation

Gingras, Marie-Claude, Covington, Kyle R., Chang, David K., Donehower, Lawrence A., Gill, Anthony J., Ittmann, Michael M., Creighton, Chad J., Johns, Amber L., Shinbrot, Eve, Dewal, Ninad, Fisher, Wil

Journal:

Year:

2016

Language:

english

File:

PDF, 3.45 MB

english, 2016

24

LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro

Wamsley, J. Jacob, Issaeva, Natalia, An, Hanbing, Lu, Xinyuan, Donehower, Lawrence A., Yarbrough, Wendell G.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.31 MB

english, 2017

25

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

Harvey, Michele, Vogel, Hannes, Morris, Danna, Bradley, Allan, Bernstein, Alan, Donehower, Lawrence A.

Journal:

Nature Genetics

Year:

1995

File:

PDF, 807 KB

1995

26

Dual Roles for the Phosphatase PPM1D in Regulating Progesterone Receptor Function

Proia, David A., Nannenga, Bonnie W., Donehower, Lawrence A., Weigel, Nancy L.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.24 MB

english, 2006

27

WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma

Richter, Mark, Dayaram, Tajhal, Gilmartin, Aidan G., Ganji, Gopinath, Pemmasani, Sandhya Kiran, Van Der Key, Harjeet, Shohet, Jason M., Donehower, Lawrence A., Kumar, Rakesh, Vinci, Maria Cristina

Journal:

Year:

2015

Language:

english

File:

PDF, 4.71 MB

english, 2015

28

Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53

Stuart D. Tyner, Jene Choi, Rodolfo Laucirica, Richard J. Ford, Lawrence A. Donehower

Journal:

Molecular Carcinogenesis

Year:

1999

Language:

english

File:

PDF, 832 KB

english, 1999

29

Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity

Lynette Moore, Xiongbin Lu, Nader Ghebranious, Stuart Tyner, Lawrence A. Donehower

Journal:

Mechanisms of Ageing and Development

Year:

2007

Language:

english

File:

PDF, 1.35 MB

english, 2007

30

The utility of genetically altered mouse models for cancer research

Lawrence A. Donehower, John E. French, Stephen D. Hursting

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

31

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

Xia, Zheng, Donehower, Lawrence A., Cooper, Thomas A., Neilson, Joel R., Wheeler, David A., Wagner, Eric J., Li, Wei

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

32

The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stability

Lu, Xiongbin, Nguyen, Thuy-Ai, Zhang, Xinna, Donehower, Lawrence A.

Journal:

Year:

2008

Language:

english

File:

PDF, 424 KB

english, 2008

33

Tumor Suppressor Dosage Regulates Stem Cell Dynamics during Aging

Gatza, Catherine, Moore, Lynette, Dumble, Melissa, Donehower, Lawrence A.

Journal:

Year:

2007

Language:

english

File:

PDF, 912 KB

english, 2007

34

Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

Tamara Terzian, Melissa Dumble, Farinaz Arbab, Christina Thaller, Lawrence A Donehower, Guillermina Lozano, Monica J Justice, Dennis R Roop, Neil F Box

Journal:

The Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 684 KB

english, 2011

35

Insights into Wild-Type and Mutant p53 Functions Provided by Genetically Engineered Mice

Donehower, Lawrence A.

Journal:

Year:

2014

Language:

english

File:

PDF, 340 KB

english, 2014

36

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

Frese, Kristopher K, Latorre, Isabel J, Chung, Sang-Hyuk, Caruana, Georgina, Bernstein, Alan, Jones, Stephen N, Donehower, Lawrence A, Justice, Monica J, Garner, Craig C, Javier, Ronald T

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 394 KB

english, 2006

37

p53, longevity assurance and longevity suppression

Lawrence A. Donehower

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2006

Language:

english

File:

PDF, 195 KB

english, 2006

38

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types

Parikh, Neha, Hilsenbeck, Susan, Creighton, Chad J, Dayaram, Tajhal, Shuck, Ryan, Shinbrot, Eve, Xi, Liu, Gibbs, Richard A, Wheeler, David A, Donehower, Lawrence A

Journal:

The Journal of Pathology

Year:

2014

Language:

english

File:

PDF, 2.96 MB

english, 2014

39

Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas

Richard S. Morrison, Fumio Yamaguchi, Hideyuki Saya, Janet M. Bruner, Alan M. Yahanda, Lawrence A. Donehower, Mitchel Berger

Journal:

Journal of Neuro-Oncology

Year:

1994

Language:

english

File:

PDF, 947 KB

english, 1994

40

Homeostatic Regulation of Base Excision Repair by a p53-Induced Phosphatase: Linking Stress Response Pathways with DNA Repair Proteins

Lu, Xiongbin, Nguyen, Thuy-Ai, Appella, Ettore, Donehower, Lawrence A.

Journal:

Year:

2004

Language:

english

File:

PDF, 331 KB

english, 2004

41

miR-130b directly targets Arhgap1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma

Satterfield, Laura, Shuck, Ryan, Kurenbekova, Lyazat, Allen-Rhoades, Wendy, Edwards, Dean, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Donehower, Lawrence A., Yustein, Jason T.

Journal:

International Journal of Cancer

Year:

2017

Language:

english

File:

PDF, 1.50 MB

english, 2017

42

Gene-targeting and the p53 tumor-suppressor gene

Arthur Sands, Lawrence A. Donehower, Allan Bradley

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 1.29 MB

english, 1994

43

Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice

Takeshi Iidaka, Tetsuya Tsukamoto, Yukari Totsuka, Akihiro Hirata, Hiroki Sakai, Norimitsu Shirai, Masami Yamamoto, Keiji Wakabayashi, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatem

Journal:

Year:

2005

Language:

english

File:

PDF, 475 KB

english, 2005

44

Cancer Prevention Studies in p53 -Deficient Mice

Hursting, Stephen D., Perkins, Susan N., Donehower, Lawrence A., Davis, Barbara J.

Journal:

Toxicologic Pathology

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

45

WIP1 dephosphorylation of p27 Kip1 Serine 140 destabilizes p27 Kip1 and reverses anti-proliferative effects of ATM phosphorylation

Choi, Byung-Kwon, Fujiwara, Kenichiro, Dayaram, Tajhal, Darlington, Yolanda, Dickerson, Joshua, Goodell, Margaret A., Donehower, Lawrence A.

Journal:

Year:

2020

Language:

english

File:

PDF, 3.53 MB

english, 2020

46

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice

Bonnie Nannenga, Xiongbin Lu, Melissa Dumble, Marc Van Maanen, Thuy-Ai Nguyen, Richard Sutton, T. Rajendra Kumar, Lawrence A. Donehower

Journal:

Molecular Carcinogenesis

Year:

2006

Language:

english

File:

PDF, 382 KB

english, 2006

47

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

Mussman, Jeffrey G, Horn, Henning F, Carroll, Patrick E, Okuda, Masaru, Tarapore, Pheruza, Donehower, Lawrence A, Fukasawa, Kenji

Journal:

Year:

2000

Language:

english

File:

PDF, 610 KB

english, 2000

48

Altered mammary gland development in the p53+/m mouse, a model of accelerated aging

Catherine E. Gatza, Melissa Dumble, Frances Kittrell, David G. Edwards, Robert K. Dearth, Adrian V. Lee, Jianming Xu, Daniel Medina, Lawrence A. Donehower

Journal:

Developmental Biology

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

49

Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

Hugh S. Gannon, Lawrence A. Donehower, Stephen Lyle, Stephen N. Jones

Journal:

Developmental Biology

Year:

2011

Language:

english

File:

PDF, 2.19 MB

english, 2011

50

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Chambers, Stuart M., Shaw, Chad A., Gatza, Catherine, Fisk, C. Joseph, Donehower, Lawrence A., Goodell, Margaret A.

Journal:

Year:

2007

Language:

english

File:

PDF, 810 KB

english, 2007

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